CK20 Positive Large-cell Neuroendocrine Carcinoma Presenting with Skin Metastases

CK20 Positive Large-cell Neuroendocrine Carcinoma Presenting with Skin Metastases

We present a case of cytokeratin (CK) 20-positive large cell neuroendocrine carcinoma (LCNEC) presenting with multiple skin metastases as the primary manifestation. The patient was a 55-year-old man who presented with a one- month history of subcutaneous skin colored nodules of various sizes on his trunk. Pathologic examination of the skin revealed a nested and solid proliferation of large undi...

Pulmonary large-cell neuroendocrine carcinoma presenting as multiple cutaneous metastases

1. Resident in Dermatology, Department of Dermatology, Curry Cabral Hospital, Centro Hospitalar de Lisboa Central, Lisbon, Portugal 2. Senior Consultant, Department of Dermatology, Curry Cabral Hospital, Centro Hospitalar de Lisboa Central, Lisbon, Portugal 3. Head, Department of Dermatology, Curry Cabral Hospital, Centro Hospitalar de Lisboa Central, Central Lisbon Hospital Center – Lisbon, Po...

lobular carcinoma of breast presenting with skin and stomach metastases

ba c k g r o u nd: skin  metastases occur  in  1-5%  of  solid  tumors  and  are  rarely the presenting sign of internal malignancies. certain features in skin lesions raise suspicion of metastasis from solid tumors. c a s e presentation: in this article a 61-year-old woman is presented with erythematous skin nodules  in  upper  abdomen  and  chest. histopathological evaluation  of  lesions sug...

Renal cell carcinoma presenting with intramyocardial metastases

Pulmonary Large-Cell Neuroendocrine Carcinoma

Lung neuroendocrine tumors are a heterogeneous sub-type of pulmonary cancers representing approximately 20% of all lung cancers, including small-cell lung cancer (SCLC) and large-cell neuroendocrine carcinoma (LCNEC). The frequency appears to be approximately 3% for LCNEC. Diagnosis of LCNEC requires attention to neuroendocrine features by light microscopy and confirmation by immunohistochemica...